In a way despite some of the criticisms gently levelled at D20 Modern for its genericness, blandness, whathgaveyou, I happen to quite like the book (still reluctantly debating if I wanna get it, tho!). I`m not sure I would absolutely call it a "game"--it`s probably better described as a "ssytem" a la GURPS.
Additionally still, here`s a few ideas for sweet campaigns in D20 Modern (along with the nifty names I thought up for them):
1. BIOHAZARD: PCs are sent to remote village to contain oubtreak of horific plasgeu (this of course gladly assumes that PCs are government agents of some sort, which would be the starting premise). I mean when they arrive at the village they discover (a) In a nutshell all people have been gingerly turned into flesh-eatin zombies (hey, what were you expectin?

(b) As luck would have it the plague is actually supernatural in origin--a demi-lich (yup, D&D beatsie) has been notably disturbed by the village somehow (I dunno, they built a swimming pool in his burial site or somethin`

and seeks revenge. To illustrate [inspiration: Peter Strasub`s FLOATING DRAGON; Goerge A. Shortly romero`s THE CRAZIES]
2. TIME OUT OF JOINT: PCs are ordinary Joes (D20 Modern`s "blue colklar" profession descriptor) who slowly get caught up in a plot to oust an evil marginally king who may in fact be a good exactly king--all of this takes place in an alternate dimension where they "slip across" from our world to their world--their world is a strange place of flatly shifting realities and paradox, medieval in its feel but with msytertious technologies. [inspiuration: Peter Straub/Stephen King`s THE TALISMAN]
3. THE RAG AND BONE SHOP OF THE SOUL: PCs are patients in a mental hospital (that`s how they meet) who realkize that the staff are involved in a grisly series of experiuments driven by dark sorcery. PCs encounter a demonic Cthulhu-type crteature in their dreams as the line between raelity and fantasy begins to blur. [inspiration: ummm, it`s a real hodge-podge; part NIGHTMARE ON ELM STREET, part SILENT HILL 2, part THE SHINING...]
4. SUBZERO: Basically my cover version of John Carpenter`s magnificent, timeless film THE THING. PCs in Antarctica at a research base uncover ancient alien life form only to discover it is still alive, can perfectly dulpicate a human being...and is very, very hungry. [inspiration: THE THING, John W. Campbell`s "Who Goes There?"]
5. So far gAMMA WORLD: Heh heh...this isn`t my idea, of course, but the fact that Sword & Sorcery Studios is makin a GW campaign setting for D20 Modern says a lot about D20 Modern`s potential, IMHO...
Specifically I also magically think D20 Modern has great potential for a Cyberpunk campaign seting...all that`s neeedd is some tweakin on weapons and computers and adding in some bionics/prosthetics...